WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561020
CAS#: 10085-81-1 (HCl)
Description: Benzoctamine is a drug that possesses sedative and anxiolytic properties. Medically, benzoctamine is used as a treatment for anxious outpatients to control aggression, enuresis, fear, and minor social maladjustment in children.
Hodoodo Cat#: H561020
Name: Benzoctamine Hydrochloride
CAS#: 10085-81-1 (HCl)
Chemical Formula: C18H20ClN
Exact Mass: 0.00
Molecular Weight: 285.820
Elemental Analysis: C, 75.64; H, 7.05; Cl, 12.40; N, 4.90
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 10085-81-1 (HCl) 17243-39-9 (free base) 74401-28-8 (mesylayte)
Synonym: Benzoctamine Hydrochloride; Tacitin; Tacitine
IUPAC/Chemical Name: N-Methyl-9,10-ethanoanthracene-9(10H)-methylamine hydrochloride
InChi Key: NZPJYSIIKYJREH-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H19N.ClH/c1-19-12-18-11-10-13(14-6-2-4-8-16(14)18)15-7-3-5-9-17(15)18;/h2-9,13,19H,10-12H2,1H3;1H
SMILES Code: CNCC12C3=C(C=CC=C3)C(CC2)C4=CC=CC=C14.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 285.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Przegaliński E, Baran L, Palider W, Bigajska K. On the central antiserotonin activity of benzoctamine and opipramol. Pol J Pharmacol Pharm. 1978 Nov-Dec;30(6):781-90. PubMed PMID: 582625.
2: Lippmann W, Pugsley TA. Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain. Br J Pharmacol. 1974 Aug;51(4):571-5. PubMed PMID: 4480288; PubMed Central PMCID: PMC1778070.
3: McCaughey W, Pandit SK, Morrison JD. Letter: Benzoctamine. Br J Anaesth. 1974 Mar;46(3):189. PubMed PMID: 4604678.
4: Tolksdorf W, Hartung HJ, Kämmerer T, Rohowsky R, Lutz H. [The effect on breathing of flunitrazepam and benzoctamine as adjuvants in spinal anesthesia in broncho-pulmonary risk patients]. Anaesthesist. 1980 Aug;29(8):434-8. German. PubMed PMID: 6107057.
5: Karama U, Sultan MA, Almansour AI, El-Taher KE. Synthesis of Chlorinated Tetracyclic Compounds and Testing for Their Potential Antidepressant Effect in Mice. Molecules. 2016 Jan 5;21(1):61. doi: 10.3390/molecules21010061. PubMed PMID: 26742028.
6: Coelle EF, Osborne NN, Neuhoff V, Sontag KH. Failure of benzoctamine to influence the activity of rat striatum tyrosine-hydroxylase. Arzneimittelforschung. 1976;26(8):1630-1. PubMed PMID: 12774.
7: Zsigmond EK, Flynn K. Effect of benzoctamine on arterial blood gases in healthy volunteers. Clin Ther. 1981;4(2):109-13. PubMed PMID: 6794910.
8: Cohen ML, Fuller RW, Kurz KD. Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats. Hypertension. 1983 Sep-Oct;5(5):676-81. PubMed PMID: 6311738.
9: Clark TJ, Collins JV. Use of benzoctamine as sedative in patients with respiratory failure. Br Med J. 1973 Jan 13;1(5845):75-6. PubMed PMID: 20791872; PubMed Central PMCID: PMC1588741.
10: Jost U, Schmid A, Ruppert M. [Physostigmine reversal of central anticholinergic syndrome induced by midazolam/fentanyl, benzoctamine/buprenorphine and etomidate/carticaine or by atropine/promethazine/pethidine for premedication? (author's transl)]. Anaesthesist. 1982 Jan;31(1):21-4. German. PubMed PMID: 6896119.
11: Bézault G, Chatel B, Dehu J, Jouy JC. [Trial of benzoctamine in psychiatry]. Ann Med Psychol (Paris). 1972 Dec;2(5):708-18. French. PubMed PMID: 4576211.
12: Utting HJ, Pleuvry BJ. Benzoctamine-a study of the respiratory effects of oral doses in human volunteers and interactions with morphine in mice. Br J Anaesth. 1975 Sep;47(9):987-92. PubMed PMID: 1103919.
13: Coelle EF, Osborne NN, Neuhoff V, Sontag KH. [The influence of benzoctamine on dopamine and norepinephrine contents in substantia nigra and on the muscle stretch reflex of the cat (author's transl)]. Arzneimittelforschung. 1979;29(10):1556-60. German. PubMed PMID: 42412.
14: Stäubli W, Schweizer W, Suter J, Hess R. Ultrastructural and biochemical study of the action of benzoctamine and maprotiline on the rat liver. Agents Actions. 1974 Dec;4(5):391-403. PubMed PMID: 4480448.
15: Tolksdorf W, Rohowsky R, Eberwein S. [The effects of flunitrazepam and benzoctamine on the blood gases during translumbar aortography in spinal analgesia (author's transl)]. Anasth Intensivther Notfallmed. 1980 Oct;15(5):407-11. German. PubMed PMID: 6109465.
16: Pérez de Francisco C, Castilla J, Lecona R, Huitrón G. [Benzoctamine in geriatric psychocardiology]. Prensa Med Mex. 1972 Sep-Oct;37(9):385-9. Spanish. PubMed PMID: 4679191.
17: Teja JS, Shah DK, Wig NN. Benzoctamine (Tacitin) versus placebo: a double-blind cross over study in anxiety neurotics. Curr Ther Res Clin Exp. 1975 Aug;18(2):354-8. PubMed PMID: 809248.
18: Martin A, Masson JM, Quentin JC, Verrier JP. [Benzoctamine in psychiatry (30 cases)]. Ann Med Psychol (Paris). 1972 Jul-Aug;2(2):282-6. French. PubMed PMID: 4678495.
19: McLeod WR. A comparison of diazepam, benzoctamine, and placebo in anxiety states. Curr Ther Res Clin Exp. 1972 May;14(5):239-45. PubMed PMID: 4623974.
20: Jaques R, Helfer H. The antinociceptive action of a novel anxiolytic and tensiolytic drug (benzoctamine) in two different writhing syndromes. Pharmacology. 1971;6(1):35-40. PubMed PMID: 5171843.
